Transcriptional Regulation of the Copper Transporter Mfc1 in Meiotic Cells
نویسندگان
چکیده
منابع مشابه
Mfc1 is a novel forespore membrane copper transporter in meiotic and sporulating cells.
To gain insight in the molecular basis of copper homeostasis during meiosis, we have used DNA microarrays to analyze meiotic gene expression in the model yeast Schizosaccharomyces pombe. Profiling data identified a novel meiosis-specific gene, termed mfc1(+), that encodes a putative major facilitator superfamily-type transporter. Although Mfc1 does not exhibit any significant sequence homology ...
متن کاملMfc1 is a novel copper transporter during meiosis
Meiosis is a specialized cell division process by which diploid germ line cells generate haploid gametes, which are required for sexual reproduction. During this process, several micronutrients are required, including copper ions. Despite important roles for copper-dependent proteins during meiosis, their mechanisms of action remain poorly understood. In a recently publication, we reported the ...
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The fission yeast Schizosaccharomyces pombe has been successfully used as a model to gain fundamental knowledge in understanding how eukaryotic cells acquire copper during vegetative growth. These studies have revealed the existence of a heteromeric Ctr4-Ctr5 plasma membrane complex that mediates uptake of copper within the cells. Furthermore, additional studies have led to the identification o...
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ژورنال
عنوان ژورنال: Eukaryotic Cell
سال: 2013
ISSN: 1535-9778,1535-9786
DOI: 10.1128/ec.00019-13